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KMID : 0603520020070010013
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Journal of Korean Association of Cancer Prevention
2002 Volume.7 No. 1 p.13 ~ p.18
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Effect of Taraxacum mongolieum Hand-Mass Ethanol Extract on Initiation of Carcinogenesis
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Shon Yun-Hee
Nam Kyung-Soo
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Abstract
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Ethanol extract of Taraxacum mongolieum Hand-Mass (TMEE) was investigated for the effect on the phase I enzyme and carcinogen-DNA adduct formation. At 2.5, 125, and 25 mg/ml of TMEE, the binding of [³H]B[a]P metabolites to DNA of NCTC-clone 1469 cells was inhibited by 38.0%, 77.8%, and 68.5%, respectively. There was slight inhibition in the activity of cytochrome P450 IAl enzyme with the treatment of TMEE. These results suggest that TMEE has chemopreventive potential by inhibiting cytochrome P450 IAl activity and benzo[a]pyrene-DNA adduct formation.
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KEYWORD
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Taraxacum mongolieum Hand-Mass, Cytochrome P450 lAI, Carcinogen-DNA adduct
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